Heidi A. Dare

Heidi Dare's practice focuses on patent prosecution and litigation as a member of the Biotech/Pharmaceutical Group.

Prior to joining the firm in 2002, Ms. Dare's non-legal experience included research associate positions with the following medical institutions and universities:

Howard Hughes Medical Institute. Research associate working on the research of Signal Transduction of Grb family proteins and responsibility for determining the binding partner of Grb 7 in breast cancer using knockout mouse technology, Western blotting, protein expression, cDNA cloning, PCR, DNA sequencing and cell culture, as well as research of gene therapy of cystic fibrosis, which research was completed in the laboratories of Dr. Francis Collins and Dr. James Wilson. Ms. Dare was responsible for cloning CFTR retroviral vectors, production of virus and characterization of transduced cell lines and conducting ADA and rLDLR gene transfer studies using bone marrow derived stem cells.

The Ohio State University. Research associate working on researching the regulation of macrophage and monocyte IL-1 beta production, and ICE regulation and responsibility for the characterization of IL-1 beta release using Western blotting, ELISA, primary cell tissue culture, immunoprecipitation and PCR.

University of Michigan. Research Assistant II responsible for primary cultivation and subcultivation of mammalian epithelial and endothelial cells, morphological and biochemical analyses of cells in culture.

• Recipient, Lederle Scholarship

• U.S. 7,456,015: Tetracycline-Regulated Adeno-Associated Viral (AAV) Vectors for Gene Delivery to the Nervous System
• E.P. 1 799 826 B1: siRNA-Mediated Silencing of a-Synuclein

• U.S. 2006/0118189: Flow Variation Valve Assembly
• U.S. 2007/0172462: siRNA-Mediated Gene Silencing of Synuclein
• U.S. 2007/0178071: Stem-Cell, Precursor Cell, or Target Cell-Based Treatment of Multiorgan Failure and Renal Dysfunction
• U.S. 2008/0027413: Blood Products from Mesenchymal Stem Cells
• U.S. 2008/0051721: Loop Tip Wire Guide

• "mLin-7 is Localized to the Basolateral Surface of Renal Epithelia Via its Aminoterminus," co-author with Straight, S., Karnak, D., Borg, J.P., Kamberov, E., Margolis, B. and Wade, J., Am J Physiol Renal Physiol., 278(3), March 2000, pp F464-75
• "Asterriquinones produced by Aspergillus candidus inhibit binding of the Grb-2 adapter to phosphorylated EGF receptor tyrosine kinase," co-author with Alvi, K.A., Pu, H., Luche, M., Rice, A., App, H., McMahon, G. and Margolis, B., J Antibiot (Tokyo), 52(3), March 1999, pp 215-23
• "Endotoxin-stimulated monocytes release multiple forms of IL-1 beta, including a proIL-1 beta form whose detection is affected by export," co-author with Wewers, M.D.and Winnard, A.V., J Immunol., 162(8), April 15, 1999, pp 4858-63
• "Expression of Grb7 growth factor receptor signaling protein in kidney development and in adult kidney," co-author with Leavey, S.F., Arend, L.J., Dressler, G.R., Briggs, J.P. and Margolis, B.L., Am J Physiol., 275(5 Pt 2), November 1998, pp F770-6
• "IL-1 beta-converting enzyme (ICE) is present and functional in human alveolar macrophages: macrophage IL-1 beta release limitation is ICE independent," co-author with Wewers, M.D., Winnard, A.V., Parker, J.M. and Miller, D.K., J Immunol.,159(12), December 15, 1997, pp 5964-72

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